Ulm
Address
University of Ulm
Dept. of Neurology
Oberer Eselsberg 45
89081 Ulm
Phone: +49 731 5000
Contact
Principle Investigator
Prof. Dr. Albert C. Ludolph
Director of the Dept. of Neurology
Phone: +49 731 500 50980
Fax: +49 731 500 50982
E-mail: albert.ludolph@rku.de
Investigator
Dr. Roman Huber
Phone: +49 731 177 1217
Fax: +49 731 177 1202
E-mail: r.huber@uni-ulm.de
Investigator
Katharina Knauer
Phone: +49 731 177 5237
Fax: +49 731 500 630 02
E-Mail: katharina.knauer@rku.de
Study Nurse
Sabine Raubold
Phone: +49 731 5006 3006
Fax: + 49 731 5006 3002
E-mail: sabine.raubold@uni-ulm.de
Concept
The stroke unit of the department of Neurology of the University of
Ulm has been founded and primarily certified as a main center of stroke
care in 1999 with a catchment population of around 500.000 people. As
admission numbers have been constantly growing over the last years the
department was expanded in 2005. Actually the facility covers 16 fully
monitored beds and comprehends all aspects of modern stroke care like a
24 hour MRI imaging unit and the possibility for neurosurgical as well
as neurointerventional procedures. An additional ambulatory for
outclinic patients has been established in 2003. The department is
constantly involved in several international multicenter trials of
acute stroke treatment as well as secondary prophylaxis of ischemic
stroke.
Link
Publications
Wolf RC, Spiess J, Vasic N, Huber R.Valvular Strands and Ischemic Stroke. Eur Neurol. 2007 Feb 20;57(4):227-231
Meisner F, Walcher D, Gizard F, Kapfer X, Huber R, Noak A, Sunder-Plassmann L, Bach H, Haug C, Bachem M, Stojakovic T, Marz W, Hombach V, Koenig W, Staels B, Marx N.: Effect of rosiglitazone treatment on plaque inflammation and collagen content in nondiabetic patients: data from a randomized placebo-controlled trial. Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):845-50.
Huber R, Kassubek J. Minor trauma may lead to traumatic
internal carotid artery dissection. Neurocrit Care. 2005;3(3):254-6.
Huber R, Riepe MW. Improved posthypoxic recovery in vitro on treatment
with drugs used for secondary stroke prevention. Neuropharmacology.
2005 Mar;48(4):558-65.
Ecker D, Geisthoff UW, Juchems M, Schneider G, Ludolph AC, Kassubek J, Huber R. [Hereditary hemorrhagic telangiectasia. A rare treatable cause of stroke] Nervenarzt. 2005 Aug;76(8):980-3.
Huber R, Spiegel T, Buchner M, Riepe MW. Graded reoxygenation with
chemical inhibition of oxidative phosphorylation improves posthypoxic
recovery in murine hippocampal slices. J Neurosci Res. 2004 Feb
1;75(3):441-9.
Riepe MW, Riss S, Bittner D, Huber R. Screening for cognitive
impairment in patients with acute stroke. Dement Geriatr Cogn Disord.
2004;17(1-2):49-53.
Hellweg R, von Arnim CA, Buchner M, Huber R, Riepe MW. Neuroprotection and neuronal dysfunction upon repetitive inhibition of oxidative phosphorylation. Exp Neurol. 2003 Oct;183(2):346-54.
Buchner M, Huber R, Riepe MW. Trans-synaptic increase of hypoxic
tolerance in hippocampus upon physical challenge with two-photon
microscopy. Hippocampus. 2002;12(6):765-73.
Huber R, Buchner M, Li H, Schlieter M, Sperfeld AD, Riepe MW. Protein binding of NADH on chemical preconditioning. J Neurochem. 2000 Jul;75(1):329-35.
Huber R, Kasischke K, Ludolph AC, Riepe MW. Increase of cellular
hypoxic tolerance by erythromycin and other antibiotics. Neuroreport.
1999 May 14;10(7):1543-6.
Kasischke K, Huber R, Li H, Timmler M, Riepe MW. Primary hypoxic
tolerance and chemical preconditioning during estrus cycle in mice.
Stroke. 1999 Jun;30(6):1256-62.
Ludolph AC, Meyer T, Riepe MW (2000) The role of excitotoxicity in ALS:
what is the evidence? J. Neurology 247: 7-16. Ludolph AC (2000):
Treatment of amyotrophic lateral sclerosis - what is the next step? J
Neurol. 247 (Suppl. 6), 13-18. Knirsch U, Bachus R, Zschenderlein R,
Gosztonyi G, Ludolph AC (2000): Clinicopathological study of atypical
motor neuron disease with vertical gaze palsy and ballism. Acta
Neuropathol 100: 342-346. Von Arnim C, Timmler M, Ludolph AC, Riepe M
(2000): Adenosine receptor up-regulation: initiated upon
preconditioning but not upheld. Neuroreport 11, 1223-1226. Münch C,
Schwalenstöcker B, Hermann C, Cirovic S, Stamm S, Ludolph AC., Meyer T
(2000): Differential RNA cleavage and polyadenylation of the glutamate
transporter EAAT2 in the human brain. Mol. Brain Res. 80: 244-251.
Winter SM, Claus A, Oberwittler C, Völkel H, Wetzler S, Ludolph AC
(2000) Recessively inherited amyotrophic lateral sclerosis: A German f
amily with the D90A Cu/Zn SOD mutation. J Neurol 247: 783-6. Gerhard A,
Neumaier B, Elitok E, Glatting G, Ries V, Tomczak R, Ludolph AC, Reske
SN (2000) In vivo imaging of activated microglia using (11C) Pk 11195
and positron emission tomography after ischemic stroke. Neuroreport 11:
2957-2960. Storch A, Burkhardt K, Ludolph AC, Schwarz J (2000)
Protective effects of riluzole on dopamine neurons: involvement of
oxidative stress and cellular energy metabolism. J. Neurochem. 75:
2259-2269. Münch C, Ludolph AC (2001): Pharmacological treatment of
ALS. Neurol Neurochir Pol 1: 41-50. Reuter A, Mi J, Sehrsam I, Ludolph
AC, Völkel H (2001): A novel calcineurin splice variant that modifies
calcineurin activity. Eur J Biochem 268: 5955-5960. Karitzky, J,
Ludolph, AC, (2001): Imaging and Neurochemical Markers for Diagnosis
and Disease Progression in ALS. J Neurol Sci. 191: 35-41. Münch C,
Penndorf A, Schwalenstöcker B, Troost D, Ludolph AC, Ince P, Meyer T
(2001): Impaired RNA splicing of 5'-regulatory sequences of the
astroglial glutmate transporter EAAT2 in human astrocytoma. J Neurol
Neurosurg Psychiatry 71 (5):675-8. Lerche H, Weber YG, Baier H,
Jurkat-Rott K, Kraus de Camargo O, Ludolph, AC, Bode H, Lehmann-Horn F
(2001): Generalized epilepsy with febrile seizures plus: further
heterogenity in a large family. Neurology 57:1191-1198.